腎不全などの高リン血症状態では、血管の石灰化が促進し、突然死や心血管イベントによる死亡リスクが 高まることが知られている。特に、高リン血症は、血管平滑筋の骨芽細胞への分化を促進し、石灰化を促すことが知られている。我々は、高リン血症が、血管内 皮機能にも影響を及ぼすことを見出し、そのメカニズムと動脈硬化との関連について研究している。また、糖代謝や脂質代謝とリン代謝との関係についても明らかにしており、リンの摂取量の過少は、生体に様々な影響を及ぼす。

（業績）

Takeda E, et al. A novel function of phosphate-mediated intracellular signal transduction pathways. Adv Enzyme Regul 46:154-161, 2006

Nishida Y, et al. Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men. Kidney Int 70(12): 2141-2147, 2006

Taketani Y, et al. Advantage of a low glycemic index and low phosphate diet on diabetic nephropathy and age-related diseases. J Med Invest 54(3-4): 359-365, 2007

Shuto E, et al. Dietary phosphorus acutely impaires endothelial function. J Am Soc Nephrol 20(7): 1504-1512, 2009

Shiota A, et al. High phosphate diet reduces atherosclerosis formation in apolipoprotein E-deficient mice. J Clin Biochem Nutr 49(12): 109-114, 2011

Tan VV, et al. Dietary phosphate restriction ameliorates endothelial dysfunction in adenine-induced kidney disease rats. J Clin Biochem Nutr 51: 27-32, 2012

Watari E, et al. Fluctuating plasma phosphorus level by changes in dietary phosphorus intake induces endothelial dysfunction. J Clin Biochem Nutr 56: 35-42, 2015

Nishi T, et al. Excessive dietary phosphorus intake impairs endothelial function in young healthy men: a time- and dose-dependent study. J Med Invest 62: 167-172, 2015

Nakao M, et al. Dietary phosphate supplementation delays the onset of iron deficiency anemia and affects iron status in rats.Nutr Res. 35(11):1016-1024, 2015

Abuduli M, et al. Effects of dietary phosphate on glucose and lipid metabolism. Am J Physiol Endocrinol Metab 310(7):E526-E538, 2016

Sugihara K, et al . Dietary phosphate exacerbates intestinal inflammation in experimental colitis. J Clin Biochem Nutr. 61(2):91-99, 2017
Kagawa T, et al. Sterol regulatory element binding protein 1 trans-activates 25-hydroxy vitamin D₃ 24-hydroxylase gene expression in renal proximal tubular cells. Biochem Biophys Res Commun. 500(2):275-282, 2018

Imi Y, et al. High phosphate diet suppresses lipogenesis in white adipose tissue. J Clin Biochem Nutr. 63(3):181-191, 2018

２）糖・脂質代謝調節とFGF21

（業績）

Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor?

Uebanso T, Taketani Y, Yamamoto H, Amo K, Ominami H, Arai H, Takei Y, Masuda M, Tanimura A, Harada N, Yamanaka-Okumura H, Takeda E.

PLoS One. 2011;6(8):e22976.

Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet.

３）妊娠期・成長期の栄養状態と生活習慣病

Induction of the hepatic stearoyl-CoA desaturase 1 gene in offspring after isocaloric administration of high fat sucrose diet during gestation.

Wanjihia VW, Ohminami H, Taketani Y, Amo K, Yamanaka-Okumura H, Yamamoto H, Takeda E.

J Clin Biochem Nutr. 2013 Nov;53(3):150-7

Regulation of α-Klotho Expression by Dietary Phosphate During Growth Periods.

４）リン負荷指数の開発

Phosphatemic Index Is a Novel Evaluation Tool for Dietary Phosphorus Load: A Whole-Foods Approach

Narasaki Y, Yamasaki M, Matsuura S, Morinishi M, Nakagawa T, Matsuno M, Katsumoto M, Nii S, Fushitani Y, Sugihara K, Noda T, Yoneda T, Masuda M. Yamanaka-Okumura H, Takeda E, Sakaue H, Yamamoto H, Taketani Y. J Renal Nutr 2020, in press

DOI:https://doi.org/10.1053/j.jrn.2020.02.005

５）慢性腎臓病の食事療法の開発

Management of phosphorus load in CKD patients.

６）栄養素の組み合わせが生体機能に及ぼす影響

Dietary combination of sucrose and linoleic acid causes skeletal muscle metabolic abnormalities in Zucker fatty rats through specific modification of fatty acid composition.

Ohminami H, Amo K, Taketani Y, Sato K, Fukaya M, Uebanso T, Arai H, Koganei M, Sasaki H, Yamanaka-Okumura H, Yamamoto H, Takeda E.

J Clin Biochem Nutr. 2014 Jul;55(1):15-25

Effects of xylitol on metabolic parameters and visceral fat accumulation.

Amo K, Arai H, Uebanso T, Fukaya M, Koganei M, Sasaki H, Yamamoto H, Taketani Y, Takeda E.

J Clin Biochem Nutr. 2011 Jul;49(1):1-7.

７）ほうれん草糖脂質の腸管粘膜保護作用

Protective effects of glycoglycerolipids extracted from spinach on 5-fluorouracil induced intestinal mucosal injury.